Matthew Kaufman, PhD

My lab studies how populations of neurons implement decision making and motor control. We record and manipulate the activity of hundreds or thousands of neurons in mouse cortex, then use sophisticated analyses to understand how these areas compute variables that the animal needs in order to behave. With calcium imaging, we can identify each neuron's cell type, layer, or projection pattern, and use this information to better understand inter-area communication and the organization of computation within cortex. With optogenetics, we can close the causal loop to determine if the activity is necessary or the roles of cell types in computation. Finally, with pharmacological manipulations, we can begin to understand how psychiatric drugs drive their behavioral effects.

Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
- Neuroscience
2018

Stanford University
Stanford, CA
PhD - Neuroscience
2011

Stanford University
Stanford, CA
BS - Symbolic Systems
2005

BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.
Huang L, Kebschull JM, Fürth D, Musall S, Kaufman MT, Churchland AK, Zador AM. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Cell. 2020 Dec 23; 183(7):2040.
PMID: 33357401

Neural population dynamics in motor cortex are different for reach and grasp.
Suresh AK, Goodman JM, Okorokova EV, Kaufman M, Hatsopoulos NG, Bensmaia SJ. Neural population dynamics in motor cortex are different for reach and grasp. Elife. 2020 11 17; 9.
PMID: 33200745

BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.
Huang L, Kebschull JM, Fürth D, Musall S, Kaufman MT, Churchland AK, Zador AM. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Cell. 2020 07 09; 182(1):177-188.e27.
PMID: 32619423

Publisher Correction: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.
O'Shea DJ, Kalanithi P, Ferenczi EA, Hsueh B, Chandrasekaran C, Goo W, Diester I, Ramakrishnan C, Kaufman MT, Ryu SI, Yeom KW, Deisseroth K, Shenoy KV. Publisher Correction: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Sci Rep. 2019 Dec 05; 9(1):18775.
PMID: 31801956

Single-trial neural dynamics are dominated by richly varied movements.
Musall S, Kaufman MT, Juavinett AL, Gluf S, Churchland AK. Single-trial neural dynamics are dominated by richly varied movements. Nat Neurosci. 2019 10; 22(10):1677-1686.
PMID: 31551604

Accurate Estimation of Neural Population Dynamics without Spike Sorting.
Trautmann EM, Stavisky SD, Lahiri S, Ames KC, Kaufman MT, O'Shea DJ, Vyas S, Sun X, Ryu SI, Ganguli S, Shenoy KV. Accurate Estimation of Neural Population Dynamics without Spike Sorting. Neuron. 2019 07 17; 103(2):292-308.e4.
PMID: 31171448

Adapting Fine with a Little Help from the Null Space.
Kaufman MT. Adapting Fine with a Little Help from the Null Space. Neuron. 2018 11 21; 100(4):771-773.
PMID: 30465761

Inferring single-trial neural population dynamics using sequential auto-encoders.
Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D. Inferring single-trial neural population dynamics using sequential auto-encoders. Nat Methods. 2018 10; 15(10):805-815.
PMID: 30224673

Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.
O'Shea DJ, Kalanithi P, Ferenczi EA, Hsueh B, Chandrasekaran C, Goo W, Diester I, Ramakrishnan C, Kaufman MT, Ryu SI, Yeom KW, Deisseroth K, Shenoy KV. Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Sci Rep. 2018 04 30; 8(1):6775.
PMID: 29712920

Perspectives on classical controversies about the motor cortex.
Omrani M, Kaufman MT, Hatsopoulos NG, Cheney PD. Perspectives on classical controversies about the motor cortex. J Neurophysiol. 2017 09 01; 118(3):1828-1848.
PMID: 28615340

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McKnight Foundation Allison Doupe Fellowship
Cold Spring Harbor Laboratory
2015 - 2015

Simons Collaboration on the Global Brain postdoctoral fellowship
Cold Spring Harbor Laboratory
2015 - 2018

Swartz Postdoctoral Fellowship
Cold Spring Harbor Laboratory
2013 - 2015

NSF GRFP
Stanford University
2006 - 2010