Nipam Patel

Over the past two decades, developmental biologists have made great strides in understanding embryonic pattern formation at the genetic, molecular, and cellular levels. Much of this advancement can be attributed to the remarkable success of studies of pattern formation in model systems, such as the fruit fly Drosophila melanogaster. Identification of genes that play major roles in setting up the body plan, combined with the subsequent discovery that many of these genes are well conserved even between different phyla, has also led to a renaissance in the investigation of the links between evolution and development. Using information collected from studies of Drosophila development, my lab and others are beginning to explore the degree to which developmental pathways have been conserved or altered between various arthropods. Insights into the nature of developmental and molecular alterations will help us to understand the evolutionary changes in the mechanisms of pattern formation and provide a molecular basis for analyzing the diversification of body morphologies and developmental mechanisms.

The crustacean model Parhyale hawaiensis.
Paris M, Wolff C, Patel NH, Averof M. The crustacean model Parhyale hawaiensis. Curr Top Dev Biol. 2022; 147:199-230.
PMID: 35337450

Mimicry can drive convergence in structural and light transmission features of transparent wings in Lepidoptera.
Pinna CS, Vilbert M, Borensztajn S, Daney de Marcillac W, Piron-Prunier F, Pomerantz A, Patel NH, Berthier S, Andraud C, Gomez D, Elias M. Mimicry can drive convergence in structural and light transmission features of transparent wings in Lepidoptera. Elife. 2021 12 21; 10.
PMID: 34930525

Developmental, cellular and biochemical basis of transparency in clearwing butterflies.
Pomerantz AF, Siddique RH, Cash EI, Kishi Y, Pinna C, Hammar K, Gomez D, Elias M, Patel NH. Developmental, cellular and biochemical basis of transparency in clearwing butterflies. J Exp Biol. 2021 05 15; 224(10).
PMID: 34047337

Developmental, cellular, and biochemical basis of transparency in clearwing butterflies.
Pomerantz AF, Siddique RH, Cash EI, Kishi Y, Pinna C, Hammar K, Gomez D, Elias M, Patel NH. Developmental, cellular, and biochemical basis of transparency in clearwing butterflies. J Exp Biol. 2021 May 10.
PMID: 33969872

N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathy.
Toma W, Caillaud M, Patel NH, Tran TH, Donvito G, Roberts J, Bagdas D, Jackson A, Lichtman A, Gewirtz DA, Makriyannis A, Malamas MS, Imad Damaj M. N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathy. Eur J Pain. 2021 07; 25(6):1367-1380.
PMID: 33675555

Autophagy and senescence in cancer therapy.
Patel NH, Bloukh S, Alwohosh E, Alhesa A, Saleh T, Gewirtz DA. Autophagy and senescence in cancer therapy. Adv Cancer Res. 2021; 150:1-74.
PMID: 33858594

Targeting Peroxisome Proliferator-Activated Receptor-a (PPAR- a) to reduce paclitaxel-induced peripheral neuropathy.
Caillaud M, Patel NH, White A, Wood M, Contreras KM, Toma W, Alkhlaif Y, Roberts JL, Tran TH, Jackson AB, Poklis J, Gewirtz DA, Damaj MI. Targeting Peroxisome Proliferator-Activated Receptor-a (PPAR- a) to reduce paclitaxel-induced peripheral neuropathy. Brain Behav Immun. 2021 03; 93:172-185.
PMID: 33434562

A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice.
Caillaud M, Patel NH, Toma W, White A, Thompson D, Mann J, Tran TH, Roberts JL, Poklis JL, Bigbee JW, Fang X, Gewirtz DA, Damaj MI. A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice. Cancers (Basel). 2020 Dec 29; 13(1).
PMID: 33383736

Knockout of crustacean leg patterning genes suggests that insect wings and body walls evolved from ancient leg segments.
Bruce HS, Patel NH. Knockout of crustacean leg patterning genes suggests that insect wings and body walls evolved from ancient leg segments. Nat Ecol Evol. 2020 12; 4(12):1703-1712.
PMID: 33262517

Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance.
Xu J, Patel NH, Gewirtz DA. Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance. Int J Mol Sci. 2020 Nov 26; 21(23).
PMID: 33256191

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